Voltage laws for three-dimensional microdomains with cusp-shaped funnels derived from Poisson-Nernst-Planck equations
نویسندگان
چکیده
We study the electro-diffusion properties of a domain containing a cusp-shaped structure in three dimensions when one ionic specie is dominant. The mathematical problem consists in solving the steady-state Poisson-Nernst-Planck (PNP) equation with an integral constraint for the number of charges. A non-homogeneous Neumann boundary condition is imposed on the boundary. We construct an asymptotic approximation for certain singular limits that agree with numerical simulations. Finally, we analyse the consequences of non-homogeneous surface charge density. We conclude that the geometry of cusp-shaped domains influences the voltage profile, specifically inside the cusp structure. The main results are summarized in the form of new three-dimensional electrostatic laws for non-electroneutral electrolytes. We discuss applications to dendritic spines in neuroscience.
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